Is activation of the granulocyte by concanavalin-A a reversible process?

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Is activation of the granulocyte by concanavalin-A a reversible process?

The stimulation of granulocyte O2- production by concanavalin-A can be reversed with alpha-methylmannoside. Such cells can be reactivated to generate O2- by adding phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine. Opsonized zymosan, however, is not an effective stimulant to these cells. alpha-Methylmannoside prevents, but does not reverse, depolarization of granulocytes by c...

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ژورنال

عنوان ژورنال: Blood

سال: 1984

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v63.1.114.bloodjournal631114